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Immune complexes in breast cancer patients as detected by Clq binding
Author(s) -
Papsidero L. D.,
Nemoto T.,
Snyderman M. C.,
Chu T. M.
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197911)44:5<1636::aid-cncr2820440515>3.0.co;2-c
Subject(s) - medicine , carcinoembryonic antigen , breast cancer , immune system , disease , immunology , cancer , malignant disease , rheumatoid factor , antibody
Levels of Clq binding activity have been measured in the sera of patients with benign and malignant breast disease. Cancer patients showed significantly higher binding activity than patients with gross fibrocystic disease. Clq binding levels were not related to levels of carcinoembryonic antigen, or rheumatoid factor. The Clq reactive material was identified as being precipitable with Protein A, and predominantly eluted in gel filtration fractions with a molecular weight of approximately 1 × 10 6 . These studies indicate that Clq binding level may be of use in the differential diagnosis of benign and malignant breast disease.