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Atypical T‐cell leukemia terminating Hodgkin's disease
Author(s) -
Boucheix Claude,
Zittoun Robert,
Reynes Michel,
Diebold Jacques,
Bernadou Alain,
BilskiPasquier Georges
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197910)44:4<1403::aid-cncr2820440434>3.0.co;2-1
Subject(s) - medicine , cytochemistry , pathology , disease , leukemia , rosette (schizont appearance) , chronic lymphocytic leukemia , immunology , cancer research , ultrastructure
Abstract A case of Hodgkin's disease is described which developed into a terminal illness characterized by a malignant proliferation of T‐cells. The leukemic cells, after optical and ultrastructural analysis, were distinct from those of myelomonocytic, acute lymphoblastic, chronic lymphocytic as well as pro‐lymphocytic leukemia. Their relationship with the T‐cell lineage seemed to be confirmed by a highly positive E‐rosette test and by cytochemistry which showed focal positivity of acid phosphatase. The importance of this T‐cell malignant proliferation is discussed, especially with regard to cellular interactions in Hodgkin's disease.