Premium
Sebaceous lymphadenoma. Ultrastructural observations and lipid analysis
Author(s) -
Tschen Jaime A.,
McGavran Malcolm H.
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197910)44:4<1388::aid-cncr2820440432>3.0.co;2-o
Subject(s) - medicine , ultrastructure , pathology
Sebaceous lymphadenoma is a rare, benign neoplasm of the parotid gland. In the 18 years since the initial report 13 seven additional cases have been published. None includes ultrastructural studies or lipid analysis. Electron microscopy shows that the epithelial cells undergo a progressive maturation from basal to the typical lipid‐laden mature sebaceous cells as in the cutaneous sebaceous glands. No morphologic differences are found between cutaneous sebaceous glands and the sebaceous glands in this parotid neoplasm. Thin layer chromatography demonstrates the same type of lipids in the sebaceous lymphadenoma as well as in cutaneous sebaceous glands. These findings suggest that the parotid salivary gland may be ectodermally rather than endodermally derived.