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Primary leiomyosarcoma of the bone and its comparison with fibrosarcoma. A cytological, histological, and ultrastructural study
Author(s) -
Sanerkin N. G.
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197910)44:4<1375::aid-cncr2820440431>3.0.co;2-0
Subject(s) - medicine , fibrosarcoma , ultrastructure , leiomyosarcoma , pathology , primary bone , sarcoma
Two cases of primary leiomyosarcoma of the bone are recorded, one in the distal fibula of a 66‐year‐old man, the other in the proximal tibia of a 61 ‐year‐old woman. The cytological, histological, and ultrastructural features of leiomyosarcoma of bone are described and compared with those of fibrosarcoma. These features are sufficiently characteristic to enable a confident diagnostic distinction between leiomyosarcoma and fibrosarcoma. Nevertheless, certain basic similarities exist between these two tumors, manifested at the ultrastructural level by the presence of myofilaments in fibrosarcoma; it would seem that the observed differences relate to the degree of development of the myofilamentous structures. It is postulated that primary leiomyosarcoma of the bone need not necessarily always arise from the media of blood vessels; it might also conceivably develop through advanced myogenic metaplasia of a sarcoma originating from fibroblastic tissue.