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Cell kinetic analyses of human malignant brain tumors (gliomas)
Author(s) -
Hoshino Takao,
Wilson Charles B.
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197909)44:3<956::aid-cncr2820440325>3.0.co;2-c
Subject(s) - medicine , glioma , human brain , pathology , cancer research , psychiatry
Administration of 3 H‐thymidine, either with or without mitostatic agents, to 24 patients with various gliomas revealed 1) in viable areas a labeling index (LI) for glioblastomas equal to 5–15%, 2) an LI of 1% or less in well‐differentiated gliomas, and 3) the LI of anaplastic astrocytomas was intermediate and reflected the extent of anaplasia. Growth fraction was 0.14–0.44 in malignant gliomas (average 0.31 ± 0.10), and cell cycle time obtained by means of stathmokinetic analysis was 75.6 ± 45.7 hr. With few exceptions, the patients whose tumors showed an LI of 5% or more died within 1 year after the onset of disease, and no patients whose tumors at biopsy had an LI of over 5% survived more than 6 months. In contrast, there was a far better prognosis for patients whose tumors demonstrated an LI of less than 1%.