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Phase I‐II study of ftorafur and methyl‐ccnu in advanced colorectal cancer
Author(s) -
Belt Robert J.,
Stephens Ronald
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197909)44:3<869::aid-cncr2820440312>3.0.co;2-f
Subject(s) - medicine , colorectal cancer , rectum , adenocarcinoma , tegafur , oncology , gastroenterology , cancer , gastrointestinal cancer
The combination of Ftorafur (NSC‐148958) and methyl‐CCNU (NSC‐95441) was evaluated in 36 patients with advanced colorectal cancer. The principle toxicities encountered were myelosuppression, gastrointestinal, and neurological. There were no complete responses and only 5/34 (14.7%) patients achieved a partial response. Methyl‐CCNU and Ftorafur does not appear to be an effective combination in advanced adenocarcinoma of the colon and rectum.