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Prognostic factors affecting remission, remission duration, and survival in adult acute nonlymphocytic leukemia
Author(s) -
Brandman James,
Bukowski R. M.,
Greenstreet Richard,
Hewlett James S.,
Hoffman George C.
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197909)44:3<1062::aid-cncr2820440339>3.0.co;2-a
Subject(s) - medicine , leukemia , survival analysis , gastroenterology , complete remission , chemotherapy
The medical records of 94 consecutive patients with acute nonlymphocytic leukemia (ANLL) were reviewed to identify significant prognostic factors. The data were analyzed using 1) Cox's linear hazard and linear logistic models, 2) chi‐square comparison of the groups living longer than 2 years and those living less than 2 years, and 3) the Gehan‐Breslow test of equal survival curves. The only statistically significant finding was that the presence of promyelocytic cell type and complete remission correlated with increased survival (p < 0.05), but this was negated by the small number of patients with this cell type. There was a suggestive association between higher initial hemoglobin and survival (p = 0.09). The Gehan‐Breslow test revealed a possible difference in survival between those patients more than 51 years of age and those less than 51 (p = 0.10). Thus none of the commonly accepted prognostic factors in acute nonlymphocytic leukemia was definitely shown to be useful. The findings of this study support an aggressive approach toward all patients with this disease.