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Clear‐cell chondrosarcoma A report of five cases including ultrastructural study
Author(s) -
Charpentier Yves Le,
Forest Michel,
Postel Michel,
Tomeno Bernard,
Abelanet René
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197908)44:2<622::aid-cncr2820440232>3.0.co;2-e
Subject(s) - chondrosarcoma , pathology , medicine , lesion , golgi apparatus , ultrastructure , anatomy , cell , biology , genetics
Five cases of clear‐cell variant of chondrosarcoma (Unni et al. 16 ) are reported. The tumors occurred in the epiphyseal region of long bones; three in the femoral head. Roentgenographically, the lesion was usually a well‐defined and benign appearing one, either purely lytic (3 cases) or with central radiodensity (2 cases). Histologically, all five cases had areas of conventional chondrosarcoma; however, the greater portion of the tumor was made up of sheets of clearcells intermixed with nonneoplastic bone trabeculae but devoid of chondroid matrix. Electron microscopic studies showed that these clear‐cells possess cytoplasmic microvilli, abundant glycogen particles and prominent golgi complexes, like normal or tumorous chondroid cells usually have. In our experience, the best treatment seemed to be en bloc resection with joint replacement; indeed, despite the fact that they are true chondrosarcomas, these tumors usually have a very slow rate of growth. Cancer 44:622‐629, 1979.