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Treatment of acute leukemia in protected environment units
Author(s) -
Bodey Gerald P.,
McCredie Kenneth B.,
Keating Michael J.,
Freireich Emil J
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197908)44:2<431::aid-cncr2820440209>3.0.co;2-4
Subject(s) - medicine , acute leukemia , leukemia , intensive care medicine
Thirty evaluable patients with acute leukemia (AL), aged 14 to 48‐years‐old, received remission induction chemotherapy on a protected environment‐prophylactic antibiotic program. Twenty‐seven (90%) of these patients achieved complete remission and 17 remained in complete remission for 1 to 22 months. Although these patients spent 36% of their time with neutrophil counts less than 100/mm3, they spent only 20% of their time with fever. Major infection was present during only 7% of the days when neutrophil count was less than 100/mm3. No patient died of an infectious complication during remission induction therapy. Cancer 44:431‐436, 1979.