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Desacetyl vinblastine amide sulfate induced ineffective erythropoiesis
Author(s) -
Jumean Hani G.,
Camitta Bruce,
Holcenberg John,
Hodach Albertina
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197907)44:1<64::aid-cncr2820440112>3.0.co;2-5
Subject(s) - anisocytosis , medicine , ineffective erythropoiesis , vinca alkaloid , erythropoiesis , vinblastine , bone marrow , red cell , leukopenia , hypoplasia , pathology , anemia , endocrinology , toxicity , chemotherapy , vincristine , cyclophosphamide
Ineffective erythropoiesis occurred during desacetyl vinblastine amide sulfate (VDS) therapy of a patient with metastatic Ewing's sarcoma. The peripheral blood was characterized by anisocytosis, poikilocytosis and reticulocytopenia. Bone marrow showed megaloblastic red cell hyperplasia with nuclear fragmentation, binuclearity and abnormal metaphases. Radioiron incorporation into red cells was markedly decreased. Electron microscopy showed red cell surface changes previously called ropalocytosis. Normal erythropoiesis promptly resumed when VDS treatment was withheld. Although less common than leukopenia, red cell abnormalities are part of the spectrum of vinca alkaloid toxicity.