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The role of chemotherapy in the treatment of Wilms' tumor
Author(s) -
Green Daniel M.,
Jaffe Norman,
Paed Dip
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197907)44:1<52::aid-cncr2820440110>3.0.co;2-i
Subject(s) - medicine , nephrectomy , chemotherapy , radiation therapy , vincristine , wilms' tumor , stage (stratigraphy) , disease , surgery , adjuvant therapy , cyclophosphamide , kidney , paleontology , biology
The records of one hundred seventy‐six patients with Wilms' tumor treated with transabdominal nephrectomy only or transabdominal nephrectomy, postoperative radiation therapy and several chemotherapy programs were reviewed. Three conclusions were reached: 1) The addition of postoperative radiation therapy and adjuvant chemotherapy has not improved the excellent, disease‐free survival of patients with Stage I disease who were less than twenty‐four months of age at diagnosis; 2) The addition of postoperative radiation therapy and adjuvant single agent chemotherapy has not improved the disease‐free survival of patients with Stage II disease who were over twelve months of age at diagnosis; and 3) The use of combination chemotherapy with vincristine and actinomycin D has improved the disease‐free survival of patients who present with Stage II disease.