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Gestational choriocarcinoma and thyrotoxicosis
Author(s) -
Anderson Norwood R.,
Lokich Jacob J.,
McDermott William V.,
Trey Charles,
Falchuk Kenneth R.
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197907)44:1<304::aid-cncr2820440151>3.0.co;2-r
Subject(s) - choriocarcinoma , medicine , human chorionic gonadotropin , endocrinology , hormone , concomitant , chorioepithelioma , gonadotropin , gestation , pregnancy , biology , genetics
A case of a 26‐year‐old woman with metastatic choriocarcinoma and clinical and biochemical thyrotoxicosis is described. This represents the eighth reported case of the association of choriocarcinoma and thyrotoxicosis. Serial monitoring of serum thyroxine (T4) and thyroid stimulating hormone (TSH) levels correlated precisely with the beta sub‐unit human chorionic gonadotropin (hCG) level and the quantitation of host tumor burden. The development of a hypermetabolic syndrome in patients with choriocarcinoma may be due to secondary thyrotoxicosis from either the TSH‐like activity of hCG or from the concomitant production of molar thyrotropin by the tumor.