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Multiple myeloma in a mink handler following exposure to aleutian disease
Author(s) -
Henry Larry W.
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197907)44:1<273::aid-cncr2820440146>3.0.co;2-c
Subject(s) - mink , hypergammaglobulinemia , asymptomatic , medicine , multiple myeloma , bence jones protein , disease , gamma globulin , immunology , virology , pathology , biology , antibody , ecology , immunoglobulin light chain
Aleutian disease of mink is a viral illness characterized by systemic plasmocytosis and hypergammaglobulinemia. Some affected mink develop a monoclonal gammaglobulin spike and Bence‐Jones proteinuria. A case of multiple myeloma in a mink handler with a 15‐year history of exposure to Aleutian mink is presented. Previously reported cases of possible Aleutian disease (AD) in man are discussed and the pathogenesis of AD reviewed. Aleutian disease virus (ADV) may produce asymptomatic infection in exposed individuals. Available data suggest symptomatic disease in humans is extremely rare.