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Electrophoresis of tissue glycosaminoglycans as an aid in the diagnosis of mesotheliomas
Author(s) -
Waxler Beverly,
Eisenstein Reuben,
Battifora Hector
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197907)44:1<221::aid-cncr2820440136>3.0.co;2-o
Subject(s) - glycosaminoglycan , hyaluronic acid , mesothelioma , pathology , medicine , context (archaeology) , electrophoresis , biochemistry , chemistry , biology , anatomy , paleontology
The histologic distinction between mesotheliomas and adenocarcinomas on mesothelial surfaces is sometimes difficult. High concentrations of hyaluronic acid in pleural and peritoneal fluids of mesothelioma patients have been reported. This paper describes results of glycosaminoglycan electrophoresis of papain digests of 7 mesotheliomas and 27 other tumors. Either all or almost all demonstrable glycosaminoglycans in mesotheliomas was hyaluronic acid. Control tissues had variable electrophoretic patterns showing other glycosaminoglycans in addition to hyaluronic acid. In the clinical context of differentiating mesotheliomas and adenocarcinomas in tissue samples, this technique seems simple, economical, and relatively specific.