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Prolactin‐secreting adenoma as part of the multiple endocrine neoplasia—type I (MEN‐I) syndrome
Author(s) -
Levine Jon H.,
Sagel Julius,
Rosebrock George,
Gonzalez Jorge J.,
Nair Raghavan,
Rawe Stephen,
Powers James M.
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197906)43:6<2492::aid-cncr2820430647>3.0.co;2-0
Subject(s) - medicine , galactorrhea , amenorrhea , pituitary tumors , prolactin , multiple endocrine neoplasia , endocrine system , adenoma , pituitary adenoma , pathology , endocrinology , gynecology , gastroenterology , pregnancy , hormone , biochemistry , chemistry , biology , gene , genetics
Two patients presented with the galactorrhea‐amenorrhea syndrome. One patient had previously had parathyroid hyperplasia and the other an insulinoma. Preoperative evaluation of each patient revealed hyperprolactinemia and radiological evidence of an abnormal sella turcica. Pituitary adenomas were identified and removed at surgery. Immunostaining techniques confirmed the presence of prolactin‐containing cells in both tumors. We propose that prolactin‐secreting tumors be considered as part of the MEN‐I syndrome, and that patients presenting with the galactorrhea‐amenorrhea syndrome be screened and followed sequentially for evidence of other endocrine neoplasia.