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Multiple‐hormone producing lung carcinoma
Author(s) -
Hattori Masahiro,
Imura Hiroo,
Matsukura Shigeru,
Yoshimoto Yoshio,
Sekita Kenichi,
Tomomatsu Tatsuya,
Kyogoku Masahisa,
Kameya Toru
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197906)43:6<2429::aid-cncr2820430639>3.0.co;2-i
Subject(s) - human chorionic gonadotropin , calcitonin , chorioepithelioma , gynecomastia , medicine , endocrinology , hormone , adrenocorticotropic hormone , choriocarcinoma , placental lactogen , prolactin , melanocyte stimulating hormone , radioimmunoassay , biology , placenta , pregnancy , fetus , genetics
Endocrine and immunohistochemical studies were performed in a patient with lung cancer associated with gynecomastia. Elevated level of human chorionic gonadotropin (hCG) in plasma and mild hyperadrenocorticism were demonstrated by hormone assays. Postmortem examination proved the existence of anaplastic small cell carcinoma of the lung mixed with a feature of chorioepithelioma. The presence of significant amounts of adrenocorticotropic hormone (ACTH), β‐melanocyte stimulating hormone (β‐MSH), calcitonin, gastrin, hCG, hCG‐α, hCG‐β and human chorionic somatomammotropin (hCS) in tumor tissues was demonstrated by radioimmunoassays, bioassay and immunohistochemical techniques. We present here a unique case of multiple hormones producing tumor elaborating both hormones of amine precursor uptake and decarboxylation (APUD) series (ACTH, β‐MSH, calcitonin and gastrin) and of placentral origin (hCG, hCG‐α, hCG‐β and hCS).