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Eosinophilia, chloromas and a chromosome abnormality in a patient with a myeloproliferative syndrome
Author(s) -
Ellman Leonard,
Hammond Denis,
Atkins Leonard
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197906)43:6<2410::aid-cncr2820430636>3.0.co;2-i
Subject(s) - medicine , abnormality , eosinophilia , chromosomal abnormality , myeloproliferative disorders , chromosome abnormality , chromosome , pathology , dermatology , karyotype , genetics , psychiatry , biology , gene
The existence of eosinophilic leukemia remains controversial since many authors challenge the existence of this entity. We present a patient with a hypereosinophilic syndrome whose findings were consistent with a leukemic process. The patient's course was marked by signs and symptoms of myeloblastoma formation and his illness terminated in an acute blastic crisis. Chromosome studies on peripheral blood leucocytes demonstrated aneuploidy and an abnormal number four chromosome with additional material on its long arm. This case appears to be an unusual example of a hypereosinophilic syndrome with both myeloblastoma formation and an abnormal leucocyte karyotype.