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Short‐term tissue culture of human breast cancer. Presence of estrogen receptors and 17 β‐estradiol stimulation of RNA synthesis
Author(s) -
Sanfilippo Ornella,
Daidone Maria Grazia,
Fronzo Giovanni Di,
Silvestrini Rosella
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197906)43:6<2365::aid-cncr2820430629>3.0.co;2-u
Subject(s) - medicine , stimulation , breast cancer , estrogen receptor , human breast , term (time) , estrogen , cancer , rna , receptor , cancer research , oncology , endocrinology , biology , biochemistry , gene , physics , quantum mechanics
The stimulation of RNA synthesis induced by estradiol has been studied on 60 breast cancers in short‐term cultures. In the same tumors the estrogen receptor (ER) assay was carried out. In 35% of the cases studied the stimulating effect by estradiol in vitro was observed. The frequency of response to in vitro hormone treatment was higher (42%) in ER + cancers and lower (25%) in ER − cancers. The specificity of the in vitro test was assessed by the use of tamoxifen.