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Chromosomes and causation of human cancer and leukemia. XXXII. Unusual features of Ph 1 ‐positive acute myeloblastic leukemia (AML), including a review of the literature
Author(s) -
Abe Syuiti,
Sandberg Avery A.
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197906)43:6<2352::aid-cncr2820430628>3.0.co;2-6
Subject(s) - clone (java method) , chromosomal translocation , acute myeloblastic leukemia , acute leukemia , chromosome , leukemia , medicine , cancer , philadelphia chromosome , biology , genetics , cancer research , gene
Five cases of Ph 1 ‐positive AML were studied. In all cases a Ph 1 ‐chromosome was shown with banding techniques to be due to a translocation between chromosomes #9 and #22. Cases 1 and 4 were found to have more than one Ph 1 with evidence of only one Ph 1 ‐translocation accompanying other chromosome abnormalities. Two cases represented an unusual pattern of appearance and disappearance of the Ph 1 ‐positive clone during their clinical courses: Case #2 was originally Ph 1 ‐positive (46,XY,Ph 1 ) but two months before his expiration, the Ph 1 ‐positive clone was completely replaced by a newly developed Ph 1 ‐negative clone with an abnormal chromosome #21 (46,XY,21q+), whereas case #3, primarily Ph 1 ‐negative, developed a Ph 1 ‐positive clone among the previously karyotypically normal cells one month before death. The Ph 1 ‐positive AML cases presented have been discussed in relation to: 1) the genesis and significance of the Ph 1 ‐positive clone, 2) differentiation from the blastic phase of CML and 3) the general experience with Ph 1 ‐positive acute non‐lymphocytic leukemia (ANLL), the world literature of which have been tabulated.