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Undifferentiated intratubular germ cell tumor of the testis. Light and electron microscopic study of a unique case
Author(s) -
Akhtar Mohammed,
Sidiki Yasmin
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197906)43:6<2332::aid-cncr2820430624>3.0.co;2-k
Subject(s) - embryonal carcinoma , seminoma , pathology , germ cell , carcinoma in situ , germ cell tumors , tunica albuginea (penis) , testicular germ cell tumor , ultrastructure , carcinoma , medicine , biology , anatomy , cellular differentiation , chemotherapy , penis , biochemistry , gene
A 34‐year‐old white man was found to have a nodule on the surface of right testis which turned out to be metastatic embryonal carcinoma within the tunica albuginea. Examination of the orchiectomy specimen revealed extensive undifferentiated intratubular germ cell tumor (carcinoma in situ ) with foci of intratubular embryonal carcinoma and seminoma. Ultrastructure of the cells comprising the carcinoma in situ was similar to that of undifferentiated germ cells. The development of intratubular embryonal carcinoma and seminoma in a testis with extensive carcinoma in situ lends further support to the concept that carcinoma in situ of the testis represents an undifferentiated germ cell tumor from which other types of germ cell tumors of the testis may evolve.