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Thyroid neoplasia following irradiation for medulloblastoma. Report of two cases
Author(s) -
Roggli Victor L.,
Estrada Rolando,
Fechner Robert E.
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197906)43:6<2232::aid-cncr2820430612>3.0.co;2-u
Subject(s) - medicine , thyroid , hyperplasia , radiation therapy , medulloblastoma , papillary thyroid cancer , adenoma , thyroid cancer , pathology , radiology
Thyroid neoplasms occurred in two patients 14 and 18 years after treatment with radiation for medulloblastoma. One patient had a papillary cancer and the other patient had multiple adenomas and a Hurthle cell adenoma. In addition, the latter case had foci of hyperplasia plus a microfollicular transformation which has not been described in association with prior thyroid irradiation. The radiation doses delivered to the thyroid through posterior cervical spinal ports (2000‐3000 roentgens) fall within the upper range of radiation dosage associated with induction of neoplastic changes within the thyroid.