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Paroxysmal nocturnal hemoglobinuria terminating as erythroleukemia
Author(s) -
Cowall David E.,
Pasquale Dominick N.,
Dekker Paul
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197905)43:5<1914::aid-cncr2820430549>3.0.co;2-q
Subject(s) - paroxysmal nocturnal hemoglobinuria , medicine , hemoglobinuria , myelodysplastic syndromes , immunology , leukemia , hemolysis , bone marrow
A case of a patient who developed erythroleukemia 3 years into the course of paroxysmal nocturnal hemoglobinuria (PNH) is presented. A case of erythroleukemia with a positive sucrose lysis test has been reported, but our case appears to be the first with a long clinical course of PNH evolving into erythroleukemia. The association between these two diseases, their possible clonal origin, and how they fit into the myelodysplastic syndromes are discussed.