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Malignant fibrosarcomatous mesothelioma and benign pleural fibroma (localized fibrous mesothelioma) in tissue culture: A comparison of the in Vitro pattern of growth in relation to the cell of origin
Author(s) -
AlvarezFernandez E.,
DiezNau M. D.
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197905)43:5<1658::aid-cncr2820430515>3.0.co;2-y
Subject(s) - mesothelioma , pathology , mesothelial cell , connective tissue , fibroma , medicine , anatomy
Two cases of fibrous mesothelioma are presented. The first is a malignant tumor containing bundles of spindle‐shaped cells with a dense reticulin network and nests of epithelial‐like cells. The second is a benign tumor made up of spindle‐shaped cells arranged in bundles with abundant reticulin and collagen fibers. Tissue culture in the first case revealed plaques similar to those formed by epithelial tumors. The second case had a fibroblastic pattern with single isolated spindle‐shaped cells. These findings confirmed the mesothelial nature of fibrosarcomatous mesothelioma and supported the view that the so‐called localized fibrous mesotheliomas could be fibroblastic neoplasms derived from the submesothelial connective tissue.