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Active specific immunotherapy with tumor cells and Corynebacterium parvum . A phase I study
Author(s) -
McCune Craig S.,
Patterson W. Bradford,
Henshaw Edgar C.
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197905)43:5<1619::aid-cncr2820430509>3.0.co;2-o
Subject(s) - medicine , immunotherapy , tumor cells , toxicity , active immunotherapy , cancer research , oncology , immunology , cancer
Autologous, irradiated (10,000 rads) tumor cells mixed with C. parvum were given as weekly intracutaneous injections to fifteen patients with residual malignant disease. The toxicity was minimal and distinctly less than has been seen with tumor cell‐BCG immunotherapy. A goal of 4 injections of 10 7 cells each was possible in only 4 patients because of limitations in methods of disaggregation and quantity of tumor available. The feasibility aspects are discussed and a case report of a prolonged regression is presented.