Premium
Hairy cell leukemia. An autopsy study
Author(s) -
Vardiman James W.,
Variakojis Daina,
Golomb Harvey M.
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197904)43:4<1339::aid-cncr2820430424>3.0.co;2-e
Subject(s) - autopsy , medicine , infiltration (hvac) , pathology , hairy cell leukemia , leukemia , lymph , pericardium , haematopoiesis , connective tissue , stem cell , immunology , biology , physics , genetics , thermodynamics
Autopsy material from 5 patients with hairy cell leukemia was examined. In addition to the expected widespread involvement of the hematopoietic system and of the liver, all of the patients had various amounts of pulmonary infiltration by leukemic cells. This infiltration was so severe in one instance that the resulting pulmonary insufficiency was the cause of death. Other areas of hairy cell infiltration included the peripancreatic connective tissue in all cases, kidneys in 3 cases, pericardium in 2 cases, and skin in 1 case. Association of plasma cells with the infiltrating neoplastic cells was prominent. In one patient, foci of large, bizarre cells were found in several lymph nodes and in the pericardium. Whether these cells represent transformation of the hairy cells into a larger, less differentiated cell type, or the emergence of a second hematopoietic neoplasm, is unknown.