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Malignant myelosclerosis (acute myelofibrosis). Report of two cases following cytotoxic chemotherapy
Author(s) -
Ali Nabil Omar,
Janes William O.
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197904)43:4<1211::aid-cncr2820430408>3.0.co;2-x
Subject(s) - pancytopenia , medicine , myelofibrosis , cytotoxic t cell , chemotherapy , pathogenesis , bone marrow , acute leukemia , pathology , leukemia , immunology , biology , biochemistry , in vitro
Malignant myelosclerosis or acute myelofibrosis is a rare acute myeloproliferative disorder characterized by pancytopenia, myeloblastosis and marrow fibrosis. We describe two patients who developed malignant myelosclerosis after receiving cytotoxic chemotherapy, one for Hodgkin's disease, and the other for membranous nephritis. In view of the known leukemogenic effect of cytotoxic drugs, we presume that chemotherapy played a role in the pathogenesis of malignant myelosclerosis in these two patients.