Premium
Steroid hormone receptors in human colon cancers
Author(s) -
Alford T. Crandall,
Do HoanMy,
Geelhoed Glenn W.,
Tsangaris Neofytos T.,
Lippman Marc E.
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197903)43:3<980::aid-cncr2820430329>3.0.co;2-r
Subject(s) - receptor , medicine , estrogen receptor , steroid hormone , hormone , hormone receptor , endocrinology , endocrine system , colorectal cancer , cancer , sex hormone receptor , steroid , estrogen , glucocorticoid receptor , breast cancer
Tumors from patients with primary colon cancer were studied for the presence of steroid hormone receptors for estrogen (E 2 ), progesterone (Prog), dihydrotestosterone (DHT) and glucocorticoid. Ten of 33 (30%) tumors contained high affinity E 2 receptors. Four were males and six females with positive assays predominantly from the left colon. Twenty‐three of these tumors were also assayed for DHT and Prog and six (26%) contained all three receptors. An additional twelve tumors had at least one receptor, so that 70% of the tumors studied contained one or more receptors. Five of 22 (23%) samples were positive for glucocorticoid receptors. Common etiological factors associated with colon and breast cancer were briefly discussed. These factors, along with the presence of hormone receptors in primary colon malignancies suggest that some large bowel cancers may be endocrine‐dependent. Cancer 43:980–984, 1979.