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Ovarian cancer. Incidence and case‐control study
Author(s) -
Annegers John F.,
Strom H.,
Decker David G.,
Dockerty Malcolm B.,
O'fallon W. Michael
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197902)43:2<723::aid-cncr2820430248>3.0.co;2-1
Subject(s) - medicine , incidence (geometry) , ovarian cancer , cancer , oncology , gynecology , optics , physics
The incidence of ovarian cancer in Rochester, Minnesota over the 40‐year period 1935 through 1974 was determined; and risk factors for epithelial ovarian cancer occurring in Rochester from 1945 to 1974 were examined in 116 patients and 464 controls. Among the characteristics studied, only nul‐liparity was found to be a significant risk factor—relative risk 1.8. Other suspected risk factors—including hypertension, obesity, age at menopause, prior therapeutic pelvic radiation, and prior exposure to exogenous estrogen—were found not to differ significantly between patients and controls. The ovarian cancer patients were found to have a significantly lower frequency of prior hysterectomy and of unilateral oophorectomy than the control group. Thus our data show that hysterectomy, even when one or both ovaries are preserved, is associated with a lower risk of subsequent ovarian cancer. Cancer 43:723–729, 1979.