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Management of asparaginase induced hemorrhagic pancreatitis complicated by pseudocyst
Author(s) -
Greenstein R.,
Nogeire C.,
Ohnuma T.,
Greenstein A.
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197902)43:2<718::aid-cncr2820430247>3.0.co;2-r
Subject(s) - medicine , pancreatitis , asparaginase , pancreatic pseudocyst , intensive care medicine , surgery , leukemia , lymphoblastic leukemia
Asparaginase induced hemorrhagic pancreatitis is a rare but serious development occurring in less than 0.5% of patients treated with this drug. Severe pancreatitis with progressive abdominal distention, toxemia, hypotension and respiratory insufficiency occurred in an 18‐year‐old patient with acute lymphoblastic leukemia following treatment with asparaginase. There was a dramatic response to high flow peritoneal lavage with rapid recovery within 24 hours from a moribund state. The subsequent development of a pseudocyst, with progressive increase in size and development of obstructive symptoms, required surgical decompression. Transgastric cystogastrostomy was successfully carried out. Cancer 43:718–722, 1979.