Premium
T‐cell leukemia with thymic involution
Author(s) -
Newcom Samuel R.,
Kadin Marshall E.
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197902)43:2<622::aid-cncr2820430232>3.0.co;2-q
Subject(s) - involution (esoterism) , lymphoblast , leukemia , pathogenesis , medicine , thymic involution , t cell leukemia , lymphoblastic leukemia , disease , t cell , cancer research , immunology , pathology , immune system , biology , neuroscience , cell culture , genetics , consciousness
The prognosis of acute lymphoblastic leukemia is affected adversely by T‐cell markers on the malignant lymphoblasts. Direct involvement of the thymus has been assumed because of frequent mediastinal enlargement in these patients and the important role of the thymus in certain mouse leukemias. We report here an adult with T‐cell leukemia and mediastinal enlargement who had physiologic involution of the thymus. The possible role of diphenylhydantoin in the pathogenesis of this disease is reviewed. The possible usefulness of Nu/Nu mouse xenografting for the study of this lethal disorder is discussed. Cancer 43:622–626, 1979.