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Evolution of karyotypes in philadelphia (Ph 1 ) chromosome‐negative chronic myelogenous leukemia
Author(s) -
Mintz Uri,
Vardiman James,
Golomb Harvey M.,
Rowley Janet D.
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197902)43:2<411::aid-cncr2820430202>3.0.co;2-2
Subject(s) - chronic myelogenous leukemia , chromosomal translocation , philadelphia chromosome , medicine , bone marrow , karyotype , pathology , leukemia , population , chromosome , cytogenetics , immunology , biology , genetics , environmental health , gene
Ten of 55 patients with chronic myelogenous leukemia (CML) diagnosed between 1972 and 1977 were found to lack the Philadelphia (Ph 1 ) chromosome. Serial clinical, morphologic, and cytogenetic studies of patients with Ph 1 negative CML showed that 30% of them had chromosomal abnormalities. Two had an extra chromosome No. 8 at the time of blast crisis, with a morphological picture of myeloblasts in the bone marrow. A third patient had a 6:14 translocation initially. Abnormalities of chromosome No. 14 are frequently seen in lymphoproliferative disorders, and the bone marrow and peripheral blood contained a significant population of lymphoblasts as well as myeloblasts. The median survival for the 10 patients was 19 months. The exact nature of Ph 1 ‐negative CML is not yet clear; the disease appears to be a distinct entity among the myeloproliferative disorders. Cancer 43:411–416, 1979.