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Growth characteristics of human skin fibroblasts in vitro . A simple experimental approach for the identification of hereditary adenomatosis of the colon and rectum
Author(s) -
Kopelovich Levy,
Pfeffer Lawrence M.,
Bias Nancy
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197901)43:1<218::aid-cncr2820430133>3.0.co;2-p
Subject(s) - rectum , in vitro , medicine , cloning (programming) , pathology , cancer research , biology , genetics , computer science , programming language
Kinetic parameters of cell growth have been studied in cultured skin fibroblasts derived from individuals with hereditary adenomatosis of the colon and rectum. The growth parameters consisted of saturation density, plating density, cloning efficiency and colony‐forming ability. The results suggest deployment of these selective assays to distinguish skin fibroblasts of presumptive ACR positive individuals from those of normal subjects in vitro .