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Postirradiation sarcoma of bone. A perspective
Author(s) -
Tountas Apostolos A.,
Fornasier Victor L.,
Harwood Andrew R.,
Leung Philip M. K.
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197901)43:1<182::aid-cncr2820430127>3.0.co;2-s
Subject(s) - contraindication , medicine , sarcoma , complication , incidence (geometry) , radiation therapy , bone sarcoma , surgery , radiology , pathology , physics , alternative medicine , optics
Ten cases of irradiation induced sarcoma of bone which fulfilled Cahan's criteria were seen in a twenty year period at the Princess Margaret Hospital. The overall incidence of this complication is 0.035% of all irradiated five year survivors. Combining our data with three other large series presented in the literature, a dose complication curve could be deduced. On the basis of the human and animal data reviewed, it was concluded that the risk of radiation induced sarcoma is so low in the dose range of modern radiotherapeutic practise that it does not represent a contraindication to the use of radiation therapy.