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Sequential hemi‐body radiotherapy in advanced multiple myeloma
Author(s) -
Jaffe Jeffrey P.,
Bosch Antonio,
Raich Peter C.
Publication year - 1979
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197901)43:1<124::aid-cncr2820430119>3.0.co;2-n
Subject(s) - medicine , multiple myeloma , nausea , radiation therapy , refractory (planetary science) , regimen , chemotherapy , bone marrow , pneumonitis , surgery , oncology , radiology , lung , physics , astrobiology
Eleven patients, with advanced multiple myeloma refractory to standard chemotherapy were treated with a regimen of sequential hemi‐body radio‐therapy consisting of 800 rad midplane in a single dose to each half. 9/10 patients experienced significant relief of skeletal pain and there were 5/11 objective tumor responses with one complete remission. Treatment‐related morbidity was significant and consisted primarily of nausea and emesis, bone marrow suppression, and pneumonitis. This therapy is helpful in the management of advanced myeloma, and should be studied earlier in the course of the disease.