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Coexistence of bilateral pheochromocytoma and pancreatic islet cell tumor. Report of a case and review of the literature
Author(s) -
Tateishi Ryuhei,
Wada Akira,
Ishiguro Shingo,
Ehara Manabu,
Sakamoto Hiromi,
Miki Tsuneharu,
Mori Yoshinori,
Matsui Yukio,
Ishikawa Osamu
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197812)42:6<2928::aid-cncr2820420657>3.0.co;2-s
Subject(s) - pheochromocytoma , medicine , multiple endocrine neoplasia , paraganglioma , pancreas , acromegaly , endocrine system , islet , medullary cavity , thyroid carcinoma , pathology , medullary thyroid cancer , adenoma , thyroid , endocrinology , hormone , insulin , growth hormone , biochemistry , chemistry , gene
A 14‐year‐old Japanese male with a previously undescribed combination of bilateral pheochromocytoma and an islet cell tumor of the pancreas is presented. The combination of endocrine neoplasms in this patient overlaps multiple endocrine neoplasia (MEN) Type 1 and Type 2. A total of 14 reported cases of MEN overlapping Type 1 and Type 2 is reviewed. Of the 14, 7 patients with acromegaly developed a paraganglioma(s), 2 patients with Sipple syndrome had a pituitary adenoma, and in the other 5 patients, an intestinal carcinoid or a pancreatic islet‐cell tumor occurred in association with either a thyroid medullary carcinoma or a paraganglioma(s). We believe that the occurrence of MEN overlapping Type 1 and Type 2 is more than a fortuitous association, and can be explained on the basis of the neuroectodermal origin. Cancer 42:2928–2934, 1978.