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Cryocrystalglobulinemia in hairy cell leukemia
Author(s) -
Krause John R.,
Nitiyanant Prawat,
Rabin Bruce S.
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197812)42:6<2798::aid-cncr2820420640>3.0.co;2-c
Subject(s) - cryoglobulin , hairy cell leukemia , medicine , leukocytosis , leukemia , antibody , hairy cell , pathology , immunology , cryoglobulinemia , hepatitis c virus , virus
A patient with hairy cell leukemia (leukemic reticuloendotheliosis) was noted to have a spurious leukocytosis caused by a spontaneously crystallizing cryoglobulin. The cryoprotein was identified as IgG λ. An intracytoplasmic immunoglobulin demonstrable within the hairy cell was also IgG λ. The cryoglobulin spontaneously disappeared over a four day period. A reliable automated count on the Coulter Model S could be obtained by prewarming the blood specimen to 37 C. Cancer 42:2798–2801, 1978.