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Peripheral T lymphocytopenia under exogenous thermal stress
Author(s) -
Bühring Malte,
BorkWölwer Lydia,
Krippner Hans
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197812)42:6<2794::aid-cncr2820420639>3.0.co;2-z
Subject(s) - lymphocytopenia , medicine , peripheral , lymphocyte , peripheral blood , in vitro , t lymphocyte , endocrinology , immunology , chemistry , biochemistry , immune system
A transient decrease in T lymphocytes in peripheral blood was observed in twelve healthy volunteers immersed in hot water baths which raised their mean rectal temperature by 1.35 C. T lymphocytes declined from 59 to 41 rel % (2p < 0.001) or from a mean of 1990 to 1300 per mm 3 . T lymphocytopenia was accompanied by a relative increase in the fraction of B lymphocytes. Total lymphocyte count remained unchanged. In vitro heating alone to 39 C did not influence the total of SRBC‐labelled lymphocytes. The findings are interpreted to be the result of a change in lymphocyte distribution with increased recirculation of mobile T lymphocytes. Cancer 42:2794–2797, 1978.