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Axillary lymph‐node and breast carcinoma interrelations in organ culture
Author(s) -
Kiricuta Ion,
Todorutiu Cornelia,
Mulea Rodica,
Risca Rodica
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197812)42:6<2710::aid-cncr2820420628>3.0.co;2-m
Subject(s) - lymph , medicine , pathology , lymph node , axillary lymph nodes , malignancy , hyperplasia , metastasis , breast cancer , follicular hyperplasia , cancer
When Stage I and II cancers of the breast and their axillary lymph nodes were grown in the same tissue culture, a phenomenon of lymphocytic migration from the nodal explants to the tumor explants was observed. The lymphocytes infiltrated in and around the tumor nodules with cytotoxic effects; concomitantly, there was lymphocytic depletion in the nodal explants. The lymphocyte migration was particularly apparent when the axillary lymph nodes showed hyperplasia of the paracortical area and/or sinus histiocytosis. No correlation was found between the migration and the histologic type of disease or the degree of malignancy, but a strong correlation was observed between 1) the migration and the presence or absence of metastases in the explanted lymph nodes, and 2) the extent of the metastatic involvement in vivo . The lymphocyte migration was present only in the patient with either uninvolved lymph nodes or only a small number (1–;3) of metastatic nodes. Cancer 42:2710–2715, 1978.