Premium
Different cell clones in bone marrow and spleen of a patient with chronic myelocytic leukemia (CML) in blastic phase
Author(s) -
Olinici C. D.,
Petrov L.,
Macavei I.,
Dobay Olga
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197812)42:6<2707::aid-cncr2820420627>3.0.co;2-5
Subject(s) - myelocytic leukemia , bone marrow , myeloid leukemia , medicine , philadelphia chromosome , chromosome , spleen , cancer research , myeloid , leukemia , karyotype , cytogenetics , pathology , biology , immunology , genetics , chromosomal translocation , gene
The chromosome study of a patient with chronic myelocytic leukemia in blastic phase revealed a 46,XY,Ph 1 /47,XY,Ph 1 ,+8 cytogenetic constitution in bone marrow cells and a 46,XY,Ph 1 /48,XY,2Ph 1 , + 19 cytogenetic constitution in spleen cells. As the cell clones exhibiting chromosome abnormalities in addition to the Ph 1 chromosome evolved apparently independently, it is suggested that the acute transformation had a bifocal, myeloid and splenic origin. Cancer 42:2707–2709, 1978.