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A study of surface markers in acute lymphocytic leukemia by using anti‐T and anti‐B lymphocyte sera
Author(s) -
Yamanaka Noboru,
Ishii Yoshifumi,
Koshiba Hirofumi,
Mikuni Chikara,
Konno Mutsuko,
Kikuchi Kokichi
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197812)42:6<2641::aid-cncr2820420620>3.0.co;2-6
Subject(s) - leukemia , null cell , medicine , thymocyte , lymphocyte , immunology , t cell leukemia , antigen , acute lymphocytic leukemia , chronic lymphocytic leukemia , t lymphocyte , t cell , biology , immune system , cell culture , lymphoblastic leukemia , genetics
Cell surface markers of 21 cases of acute lymphocytic leukemia (ALL) were studied with various surface markers, especially by using anti‐human B lymphocyte serum (ABS), anti‐human thymocyte serum (ATS‐T) and anti‐human peripheral T lymphocyte serum (ALS‐T) which were rendered specific for human B lymphocytes, human thymocytes and human peripheral T lymphocytes. The proportion of cell types in ALL was null cell leukemia 38%, B cell leukemia 38% and T cell leukemia 24%, respectively. T‐ALL cells were reactive to ATS‐T but not to ALS‐T, a fact which suggests their thymic origin. It should be noted that these anti‐lymphocyte sera detected T or B marker antigens, even when other markers showed negative. Twelve patients with ALL were also investigated from their clinical pictures. Patients with B cell leukemia had severe signs of anemia and a higher grade of hepato‐splenomegalies than other types in ALL. Patients with T cell leukemia were in older age levels and had a poorer prognosis. Cancer 42:2641–2647, 1978.