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Vinblastine, adriamycin, thiotepa, and halotestin (VATH). Therapy for advanced breast cancer refractory to prior chemotherapy
Author(s) -
Perloff Marjorie,
Hart Ronald D.,
Holland James F.
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197812)42:6<2534::aid-cncr2820420605>3.0.co;2-p
Subject(s) - thiotepa , medicine , chemotherapy , vinblastine , breast cancer , refractory (planetary science) , regimen , combination chemotherapy , surgery , oncology , cancer , chemotherapy regimen , cyclophosphamide , physics , astrobiology
Nineteen postmenopausal patients with metastatic breast cancer refractory to conventional combination chemotherapy were treated with monthly cycles with the combination of vinblastine, adriamycin, thiotepa and halotestin. Ten patients (52%) responded with a greater than 50% regression of measurable tumor. The median duration of response was 11.5 months, with 5/10 patients still responding at a mean follow‐up of 10 months. Only 2/10 responders have died with a mean follow‐up of 13.8 months. In contrast, 8/9 nonresponders have died (median survival 6.0 months). Response to therapy was neither in fluenced by site of disease, time interval from diagnosis to primary chemotherapy nor duration of response to primary chemotherapy. No patient was hospitalized because of drug induced toxicity. This combination of drugs is a tolerable effective regimen for patients relapsing after adjuvant chemotherapy or after primary combination chemotherapy for grossly metastatic disease. Cancer 42:2534–2537, 1978.