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Characterization of an ovarian carcinoma cell line
Author(s) -
Freedman R. S.,
Pihl E.,
Kusyk C.,
Gallager H. S.,
Rutledge F.
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197811)42:5<2352::aid-cncr2820420536>3.0.co;2-#
Subject(s) - medicine , ovarian carcinoma , carcinoma , oncology , gynecology , ovary , ovarian cancer , cancer research , cancer
A long‐term ovarian carcinoma cell line is described in terms of its morphology, original histopathology, electron microscopic features and chromosome features before and after transplantation into an athymic nude mouse. The microscopic features of the tumor nodule grown in the nude mouse are compared with the original pathology. Epithelial characteristics of the cells were maintained in culture and after retrieval from the nude mouse. Three markers were identified in all karyotypes and trisomy was noted in chromosomes 1, 2, 3, 6, 11, 12, 16, and × and monosomy of 17 and 21. Cancer 42:2352–2359, 1978.