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Trabecular carcinoma of the skin. An ultrastructural study
Author(s) -
Tang ChikKwun,
Toker Cyril
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197811)42:5<2311::aid-cncr2820420531>3.0.co;2-l
Subject(s) - ultrastructure , pathology , carcinoma , merkel cell , medicine , frozen section procedure , electron microscope , carcinoma cell , anatomy , merkel cell carcinoma , physics , optics
We report the electron microscopic studies of three trabecular carcinomas of the skin. The presence of neurosecretory granules in all three tumors suggests that trabecular carcinoma originates from one of the neurocrest derivatives, most probably, Merkel cells. The ultrastructural findings confirm Toker's original concept that trabecular carcinomas comprise a distinct group of skin tumor. The recognition of these tumors would enable one to make such a diagnosis on frozen section, which, in turn, might provide an opportunity for more specific cytochemical and immunofluorescent characterization. Cancer 42:2311–2321, 1978.