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Multiple red cell antigen loss in acute granulocytic leukemia
Author(s) -
Kolins Jerry,
Holland Paul V.,
McGinniss Mary H.
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197811)42:5<2248::aid-cncr2820420524>3.0.co;2-t
Subject(s) - medicine , leukemia , antigen , immunology , virology
Loss of certain red blood cell antigens has been described in various disease states including acute granulocytic leukemia (AGL). This paper describes the loss of blood group A antigen in three patients, two with AGL and a third with a myeloproliferative disorder similar to AGL which developed following total body irradiation for malignant, well‐differentiated lymphocytic lymphoma. In the latter case, the onset of the myeloproliferative disease correlated with the loss of A antigen. In addition to A antigen loss, all three patients' red cells showed the loss of Lewis b antigen, a finding previously unreported. Finally, the two patients with AGL also exhibited the loss of I antigen from their red cells. Cancer 42:2248–2253, 1978.