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The role of radiation therapy in the treatment of pediatric non‐Hodgkin's lymphomas
Author(s) -
Carabell Steven C.,
Cassady J. Robert,
Weinstein Howard J.,
Jaffe Norman
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197811)42:5<2193::aid-cncr2820420517>3.0.co;2-y
Subject(s) - medicine , radiation therapy , lymphoma , oncology , dermatology
Between 1971 and 1976, 64 patients less than 18 years of age with non‐Hodgkin's lymphoma were treated at Boston's Children's Hospital Medical Center‐Joint Center for Radiation Therapy. A multimodality approach was used, consisting of radiation therapy (3500‐4500 rad), surgery, and chemotherapy. Since 1973, all patients have received a regimen initially comprising Adriamycin, Prednisone, 6‐Mercaptopurine, Vincristine, and L‐Asparaginase. Methotrexate was substituted for Adriamycin following a cumulative total dose of 450 mg/m 2 . The 5‐year actuarial survival for all patients was 61%, while relapse‐free survival was 54%. The actuarial and relapse‐free survival for patients presenting with localized disease was 75% and 72%, respectively. Median follow‐up was 40 months and all relapses occurred within 24 months of initial therapy. A multidisciplinary approach, such as the current regimen, offers a good prognosis for this disease. Cancer 42:2193–2205, 1978.