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24‐Hour infusion of cis‐platinum in head and neck cancers
Author(s) -
Jacobs Charlotte,
Bertino Joseph R.,
Goffinet Don R.,
Fee Willard E.,
Goode Richard L.
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197811)42:5<2135::aid-cncr2820420508>3.0.co;2-w
Subject(s) - medicine , head and neck , head and neck cancer , oncology , surgery , cancer
Eighteen patients with advanced squamous cell cancer of the head and neck were treated with cis‐diamminedichloroplatinum in a 24‐hour infusion. The most frequent dose used was 80 mg/m 2 repeated every three weeks. Six were treated preoperatively for Stage III or IV disease, and twelve were treated for recurrent disease. The overall response rate was 72% with one complete remission, >50% regression in six patients, and 25‐50% regression in six patients. Toxicity was minimal: creatinine >2 in 6% of courses, leukopenia in 9%, anemia in 29%, vomiting in 76%, and documented minimal hearing loss in one patient. Plasma and urine platinum levels during infusion are presented. The dosage of 80 mg/m 2 administered over 24 hours gives a response rate in head and neck cancers equivalent to that reported with higher doses given by rapid infusion, and toxicity is minimal. Cancer 42:2135–2140, 1978.