Premium
Immune response of prostatic cancer patients to cytomegalovirus‐infected and ‐transformed human cells
Author(s) -
Laychock Anna Marie,
Geder Laszlo,
Sanford Edgar J.,
Rapp Fred
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197810)42:4<1766::aid-cncr2820420415>3.0.co;2-o
Subject(s) - medicine , antigen , cancer , cytomegalovirus , immune system , hyperplasia , bladder cancer , antibody , immunofluorescence , immunology , cellular immunity , carcinoma , titer , virus , pathology , herpesviridae , viral disease
The indirect immunofluorescence test was used to determine the prevalence of humoral immunity to cytomegalovirus (CMV)‐induced antigens in prostatic cancer patients as compared to age‐matched controls. Significantly more prostatic cancer patients demonstrated high CMV‐antibody titers than did the benign prostatic hyperplasia and nonurogenital cancer groups; however, no significant difference in reactivity was found between patients with prostatic cancer and transitional cell carcinoma of the urinary bladder. When screened against CMV‐transformed human cell lines, the reactivity of the sera followed the rate of expression of CMV‐related antigens of cell lines used in these tests. Cancer 42:1766–1771, 1978.