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Diffuse pulmonary malignant mesothelioma. Response to doxorubicin and 5‐azacytidine
Author(s) -
Chahinian A. Philippe,
Suzuki Yasunosuke,
Mandel Eugen M.,
Holland James F.
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197810)42:4<1687::aid-cncr2820420405>3.0.co;2-n
Subject(s) - medicine , mesothelioma , pathology , reticular connective tissue , asbestos , lung cancer , doxorubicin , biopsy , lung , respiratory disease , chemotherapy , materials science , metallurgy
A 46‐year‐old patient who developed a right pleural mesothelioma 18 years after asbestos exposure was found to have diffuse reticular nodular infiltrates in both lungs. Lung biopsy by fiberoptic bronchoscopy revealed alveolar and interstitial spread of the neoplastic cells. A dramatic clinical and radiologic response occurred after treatment with a combination of doxorubicin (Adria‐mycin) and 5‐Azacytidine. Cancer 42:1687–1691, 1978.