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Human colon tumors. Enzymic and histological characteristics
Author(s) -
Herzfeld A.,
Legg M. A.,
Greengard O.
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197809)42:3<1280::aid-cncr2820420337>3.0.co;2-p
Subject(s) - adenocarcinoma , thymidine kinase , enzyme , reductase , dehydrogenase , phosphatase , alkaline phosphatase , medicine , biochemistry , pathology , biology , immunology , cancer , virus , herpes simplex virus
In samples of colonic adenocarcinomas, the mean activities of thymidine kinase, glucose‐6‐phosphate dehydrogenase, phosphoserine phosphatase and pyrroline‐5‐carboxylate reductase were several fold higher than those of non‐neoplastic colon. The presence of considerable, told labile pyrroline‐5‐carboxylate reductase activity provided an additional criterion for distinguishing tumors from the control tissue. Deviations from the pattern of enzymes in normal colon were much more pronounced in the five moderately well‐differentiated than in the single well‐differentiated adenocarcinoma.