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Immunoperoxidase detection of carcinoembryonic antigen. An overview
Author(s) -
Primus F. James,
Sharkey Robert M.,
Hansen Hans J.,
Goldenberg David M.
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197809)42:3+<1540::aid-cncr2820420828>3.0.co;2-y
Subject(s) - immunoperoxidase , carcinoembryonic antigen , antigen , pathology , immunohistochemistry , medicine , antibody , immunocytochemistry , immunology , monoclonal antibody , cancer
The advent of immunoperoxidase histochemistry techniques has allowed the more convenient visualization by light microscopy of antigenic cellular constituents. Application of the unlabeled and labeled antibody enzyme methods to the localization of carcinoembryonic antigen in conventionally prepared tissue specimens has revealed the feasibility of using immunoperoxidase techniques in routine diagnostic pathology. The methods involved are well defined and once antibody specificity and antigen stability are determined, they are adaptable to the identification of other immunological markers that may appear in malignant tissue specimens.